diff --git a/src/resolve/resolved-link-bus.c b/src/resolve/resolved-link-bus.c
index ba5b00c239..a269414ccf 100644
--- a/src/resolve/resolved-link-bus.c
+++ b/src/resolve/resolved-link-bus.c
@@ -398,7 +398,10 @@ int bus_link_method_set_domains(sd_bus_message *message, void *userdata, sd_bus_
                         changed = true;
                 }
 
-                d->route_only = route_only;
+                if (d->route_only != route_only) {
+                        d->route_only = route_only;
+                        changed = true;
+                }
         }
 
         r = sd_bus_message_exit_container(message);
diff --git a/test/units/TEST-75-RESOLVED.sh b/test/units/TEST-75-RESOLVED.sh
index ce7675e8ce..85e9e4cc84 100755
--- a/test/units/TEST-75-RESOLVED.sh
+++ b/test/units/TEST-75-RESOLVED.sh
@@ -280,6 +280,16 @@ manual_testcase_01_resolvectl() {
     resolvectl domain hoge "hoge.example.com"
     assert_in 'hoge.example.com' "$(resolvectl domain hoge)"
     assert_not_in '~.' "$(resolvectl domain hoge)"
+
+    local hoge_state
+    hoge_state="/run/systemd/resolve/netif/$(cat /sys/class/net/hoge/ifindex)"
+    resolvectl domain hoge "route-only-change.example.com"
+    assert_in "DOMAINS=route-only-change.example.com" "$(cat "$hoge_state")"
+    assert_in "route-only-change.example.com" "$(cat /run/systemd/resolve/resolv.conf /run/systemd/resolve/stub-resolv.conf)"
+    resolvectl domain hoge "~route-only-change.example.com"
+    assert_in "DOMAINS=~route-only-change.example.com" "$(cat "$hoge_state")"
+    assert_not_in "route-only-change.example.com" "$(cat /run/systemd/resolve/resolv.conf /run/systemd/resolve/stub-resolv.conf)"
+
     echo -e "nameserver 10.0.2.1\ndomain test-domain.example.com" | SYSTEMD_INVOKED_AS=resolvconf resolvectl -x -a hoge
     assert_in 'test-domain.example.com' "$(resolvectl domain hoge)"
     assert_in '~.' "$(resolvectl domain hoge)"