diff --git a/src/basic/missing_syscall.h b/src/basic/missing_syscall.h
index f590b91c66..f9a541af80 100644
--- a/src/basic/missing_syscall.h
+++ b/src/basic/missing_syscall.h
@@ -391,6 +391,8 @@ static inline int missing_bpf(int cmd, union bpf_attr *attr, size_t size) {
 #      define __NR_pkey_mprotect 394
 #    elif defined __powerpc__
 #      define __NR_pkey_mprotect 386
+#    elif defined __s390__
+#      define __NR_pkey_mprotect 384
 #    elif defined _MIPS_SIM
 #      if _MIPS_SIM == _MIPS_SIM_ABI32
 #        define __NR_pkey_mprotect 4363
diff --git a/src/shared/seccomp-util.c b/src/shared/seccomp-util.c
index 498e8ee84a..4e605523d9 100644
--- a/src/shared/seccomp-util.c
+++ b/src/shared/seccomp-util.c
@@ -1521,6 +1521,7 @@ int seccomp_memory_deny_write_execute(void) {
                 switch (arch) {
 
                 case SCMP_ARCH_X86:
+                case SCMP_ARCH_S390:
                         filter_syscall = SCMP_SYS(mmap2);
                         block_syscall = SCMP_SYS(mmap);
                         shmat_syscall = SCMP_SYS(shmat);
@@ -1545,13 +1546,14 @@ int seccomp_memory_deny_write_execute(void) {
                 case SCMP_ARCH_X86_64:
                 case SCMP_ARCH_X32:
                 case SCMP_ARCH_AARCH64:
-                        filter_syscall = SCMP_SYS(mmap); /* amd64, x32, and arm64 have only mmap */
+                case SCMP_ARCH_S390X:
+                        filter_syscall = SCMP_SYS(mmap); /* amd64, x32, s390x, and arm64 have only mmap */
                         shmat_syscall = SCMP_SYS(shmat);
                         break;
 
                 /* Please add more definitions here, if you port systemd to other architectures! */
 
-#if !defined(__i386__) && !defined(__x86_64__) && !defined(__powerpc__) && !defined(__powerpc64__) && !defined(__arm__) && !defined(__aarch64__)
+#if !defined(__i386__) && !defined(__x86_64__) && !defined(__powerpc__) && !defined(__powerpc64__) && !defined(__arm__) && !defined(__aarch64__) && !defined(__s390__) && !defined(__s390x__)
 #warning "Consider adding the right mmap() syscall definitions here!"
 #endif
                 }