diff --git a/test/test-network/systemd-networkd-tests.py b/test/test-network/systemd-networkd-tests.py
index b650b34f98..93ad563500 100755
--- a/test/test-network/systemd-networkd-tests.py
+++ b/test/test-network/systemd-networkd-tests.py
@@ -81,10 +81,10 @@ valgrind_cmd = ''
 enable_debug = True
 env = {}
 wait_online_env = {}
-asan_options = None
-lsan_options = None
-ubsan_options = None
-with_coverage = False
+asan_options = os.getenv('ASAN_OPTIONS')
+lsan_options = os.getenv('LSAN_OPTIONS')
+ubsan_options = os.getenv('UBSAN_OPTIONS')
+with_coverage = os.getenv('COVERAGE_BUILD_DIR') != None
 show_journal = True # When true, show journal on stopping networkd.
 
 active_units = []
@@ -487,7 +487,19 @@ def create_service_dropin(service, command, additional_settings=None):
     if ubsan_options:
         drop_in += [f'Environment=UBSAN_OPTIONS="{ubsan_options}"']
     if asan_options or lsan_options or ubsan_options:
-        drop_in += ['SystemCallFilter=']
+        # Disable system call filter when running with sanitizers, as they seem to call filtered syscall at
+        # the very end of the execution and stuck the process. See issue #39567.
+        drop_in += [
+            'LockPersonality=no',
+            'ProtectClock=no',
+            'ProtectKernelLogs=no',
+            'RestrictAddressFamilies=',
+            'RestrictNamespaces=no',
+            'RestrictRealtime=no',
+            'RestrictSUIDSGID=no',
+            'SystemCallArchitectures=',
+            'SystemCallFilter=',
+        ]
     if use_valgrind or asan_options or lsan_options or ubsan_options:
         drop_in += ['MemoryDenyWriteExecute=no']
     if use_valgrind: