diff --git a/src/basic/fd-util.c b/src/basic/fd-util.c
index a6a63454fc..5f17ed1792 100644
--- a/src/basic/fd-util.c
+++ b/src/basic/fd-util.c
@@ -1001,13 +1001,13 @@ int fd_verify_safe_flags_full(int fd, int extra_flags) {
         if (flags < 0)
                 return -errno;
 
-        unexpected_flags = flags & ~(O_ACCMODE|O_NOFOLLOW|RAW_O_LARGEFILE|extra_flags);
+        unexpected_flags = flags & ~(O_ACCMODE_STRICT|O_NOFOLLOW|RAW_O_LARGEFILE|extra_flags);
         if (unexpected_flags != 0)
                 return log_debug_errno(SYNTHETIC_ERRNO(EREMOTEIO),
                                        "Unexpected flags set for extrinsic fd: 0%o",
                                        (unsigned) unexpected_flags);
 
-        return flags & (O_ACCMODE | extra_flags); /* return the flags variable, but remove the noise */
+        return flags & (O_ACCMODE_STRICT | extra_flags); /* return the flags variable, but remove the noise */
 }
 
 int read_nr_open(void) {
@@ -1132,7 +1132,7 @@ int fds_are_same_mount(int fd1, int fd2) {
 }
 
 const char* accmode_to_string(int flags) {
-        switch (flags & O_ACCMODE) {
+        switch (flags & O_ACCMODE_STRICT) {
         case O_RDONLY:
                 return "ro";
         case O_WRONLY:
diff --git a/src/basic/fs-util.c b/src/basic/fs-util.c
index 655f59a548..2f16b6a5a7 100644
--- a/src/basic/fs-util.c
+++ b/src/basic/fs-util.c
@@ -1036,7 +1036,7 @@ int open_mkdir_at_full(int dirfd, const char *path, int flags, XOpenFlags xopen_
 
         if (flags & ~(O_RDONLY|O_CLOEXEC|O_DIRECTORY|O_EXCL|O_NOATIME|O_NOFOLLOW|O_PATH))
                 return -EINVAL;
-        if ((flags & O_ACCMODE) != O_RDONLY)
+        if ((flags & O_ACCMODE_STRICT) != O_RDONLY)
                 return -EINVAL;
 
         /* Note that O_DIRECTORY|O_NOFOLLOW is implied, but we allow specifying it anyway. The following
diff --git a/src/basic/missing_fcntl.h b/src/basic/missing_fcntl.h
index 3c3f3a445f..b767186a4a 100644
--- a/src/basic/missing_fcntl.h
+++ b/src/basic/missing_fcntl.h
@@ -43,3 +43,9 @@
 #ifndef AT_HANDLE_FID
 #define AT_HANDLE_FID AT_REMOVEDIR
 #endif
+
+/* On musl, O_ACCMODE is defined as (03|O_SEARCH), unlike glibc which defines it as
+ * (O_RDONLY|O_WRONLY|O_RDWR). Additionally, O_SEARCH is simply defined as O_PATH. This changes the behaviour
+ * of O_ACCMODE in certain situations, which we don't want. This definition is copied from glibc and works
+ * around the problems with musl's definition. */
+#define O_ACCMODE_STRICT (O_RDONLY|O_WRONLY|O_RDWR)
diff --git a/src/core/exec-invoke.c b/src/core/exec-invoke.c
index ef129eb770..0bf6c83601 100644
--- a/src/core/exec-invoke.c
+++ b/src/core/exec-invoke.c
@@ -267,7 +267,7 @@ static int acquire_path(const char *path, int flags, mode_t mode) {
 
         assert(path);
 
-        if (IN_SET(flags & O_ACCMODE, O_WRONLY, O_RDWR))
+        if (IN_SET(flags & O_ACCMODE_STRICT, O_WRONLY, O_RDWR))
                 flags |= O_CREAT;
 
         fd = open(path, flags|O_NOCTTY, mode);
@@ -291,9 +291,9 @@ static int acquire_path(const char *path, int flags, mode_t mode) {
         if (r < 0)
                 return r;
 
-        if ((flags & O_ACCMODE) == O_RDONLY)
+        if ((flags & O_ACCMODE_STRICT) == O_RDONLY)
                 r = shutdown(fd, SHUT_WR);
-        else if ((flags & O_ACCMODE) == O_WRONLY)
+        else if ((flags & O_ACCMODE_STRICT) == O_WRONLY)
                 r = shutdown(fd, SHUT_RD);
         else
                 r = 0;
diff --git a/src/libsystemd/sd-journal/journal-file.c b/src/libsystemd/sd-journal/journal-file.c
index 30a5c716a8..a0e618cf1d 100644
--- a/src/libsystemd/sd-journal/journal-file.c
+++ b/src/libsystemd/sd-journal/journal-file.c
@@ -98,7 +98,7 @@ DEFINE_HASH_OPS_WITH_VALUE_DESTRUCTOR(
                 JournalFile, journal_file_close);
 
 static int mmap_prot_from_open_flags(int flags) {
-        switch (flags & O_ACCMODE) {
+        switch (flags & O_ACCMODE_STRICT) {
         case O_RDONLY:
                 return PROT_READ;
         case O_WRONLY:
@@ -4075,10 +4075,10 @@ int journal_file_open(
         assert(mmap_cache);
         assert(ret);
 
-        if (!IN_SET((open_flags & O_ACCMODE), O_RDONLY, O_RDWR))
+        if (!IN_SET((open_flags & O_ACCMODE_STRICT), O_RDONLY, O_RDWR))
                 return -EINVAL;
 
-        if ((open_flags & O_ACCMODE) == O_RDONLY && FLAGS_SET(open_flags, O_CREAT))
+        if ((open_flags & O_ACCMODE_STRICT) == O_RDONLY && FLAGS_SET(open_flags, O_CREAT))
                 return -EINVAL;
 
         if (fname && (open_flags & O_CREAT) && !endswith(fname, ".journal"))
diff --git a/src/libsystemd/sd-journal/journal-file.h b/src/libsystemd/sd-journal/journal-file.h
index 669c066156..35f8f6ce6b 100644
--- a/src/libsystemd/sd-journal/journal-file.h
+++ b/src/libsystemd/sd-journal/journal-file.h
@@ -1,7 +1,6 @@
 /* SPDX-License-Identifier: LGPL-2.1-or-later */
 #pragma once
 
-#include <fcntl.h>
 #include <inttypes.h>
 #include <sys/uio.h>
 
@@ -15,6 +14,7 @@
 #include "compress.h"
 #include "hashmap.h"
 #include "journal-def.h"
+#include "missing_fcntl.h"
 #include "mmap-cache.h"
 #include "sparse-endian.h"
 #include "time-util.h"
@@ -391,5 +391,5 @@ static inline uint32_t COMPRESSION_TO_HEADER_INCOMPATIBLE_FLAG(Compression c) {
 
 static inline bool journal_file_writable(JournalFile *f) {
         assert(f);
-        return (f->open_flags & O_ACCMODE) != O_RDONLY;
+        return (f->open_flags & O_ACCMODE_STRICT) != O_RDONLY;
 }
diff --git a/src/login/logind-session-dbus.c b/src/login/logind-session-dbus.c
index 126020acf1..5e374ae91e 100644
--- a/src/login/logind-session-dbus.c
+++ b/src/login/logind-session-dbus.c
@@ -536,7 +536,7 @@ static int method_set_tty(sd_bus_message *message, void *userdata, sd_bus_error
         flags = fcntl(fd, F_GETFL, 0);
         if (flags < 0)
                 return -errno;
-        if ((flags & O_ACCMODE) != O_RDWR)
+        if ((flags & O_ACCMODE_STRICT) != O_RDWR)
                 return -EACCES;
         if (FLAGS_SET(flags, O_PATH))
                 return -ENOTTY;
diff --git a/src/mountfsd/mountwork.c b/src/mountfsd/mountwork.c
index a693419eec..9567146fdc 100644
--- a/src/mountfsd/mountwork.c
+++ b/src/mountfsd/mountwork.c
@@ -99,7 +99,7 @@ static int validate_image_fd(int fd, MountImageParameters *p) {
         if (fl < 0)
                 return log_debug_errno(fl, "Image file descriptor has unsafe flags set: %m");
 
-        switch (fl & O_ACCMODE) {
+        switch (fl & O_ACCMODE_STRICT) {
 
         case O_RDONLY:
                 p->read_only = true;
diff --git a/src/shared/data-fd-util.c b/src/shared/data-fd-util.c
index 6f4825d8c1..20d54f325d 100644
--- a/src/shared/data-fd-util.c
+++ b/src/shared/data-fd-util.c
@@ -146,13 +146,13 @@ int memfd_clone_fd(int fd, const char *name, int mode) {
 
         assert(fd >= 0);
         assert(name);
-        assert(IN_SET(mode & O_ACCMODE, O_RDONLY, O_RDWR));
+        assert(IN_SET(mode & O_ACCMODE_STRICT, O_RDONLY, O_RDWR));
         assert((mode & ~(O_RDONLY|O_RDWR|O_CLOEXEC)) == 0);
 
         if (fstat(fd, &st) < 0)
                 return -errno;
 
-        ro = (mode & O_ACCMODE) == O_RDONLY;
+        ro = (mode & O_ACCMODE_STRICT) == O_RDONLY;
         exec = st.st_mode & 0111;
 
         mfd = memfd_create_wrapper(name,
diff --git a/src/shared/journal-file-util.c b/src/shared/journal-file-util.c
index b352ede275..edd5056ad9 100644
--- a/src/shared/journal-file-util.c
+++ b/src/shared/journal-file-util.c
@@ -504,7 +504,7 @@ int journal_file_open_reliably(
                     -EIDRM))            /* File has been deleted */
                 return r;
 
-        if ((open_flags & O_ACCMODE) == O_RDONLY)
+        if ((open_flags & O_ACCMODE_STRICT) == O_RDONLY)
                 return r;
 
         if (!(open_flags & O_CREAT))
@@ -519,7 +519,7 @@ int journal_file_open_reliably(
         /* The file is corrupted. Try opening it read-only as the template before rotating to inherit its
          * sequence number and ID. */
         r = journal_file_open(-EBADF, fname,
-                              (open_flags & ~(O_ACCMODE|O_CREAT|O_EXCL)) | O_RDONLY,
+                              (open_flags & ~(O_ACCMODE_STRICT|O_CREAT|O_EXCL)) | O_RDONLY,
                               file_flags, 0, compress_threshold_bytes, NULL,
                               mmap_cache, /* template = */ NULL, &old_file);
         if (r < 0)
diff --git a/src/shared/loop-util.c b/src/shared/loop-util.c
index 4a6e0046df..5f2fe03e2e 100644
--- a/src/shared/loop-util.c
+++ b/src/shared/loop-util.c
@@ -500,7 +500,7 @@ static int loop_device_make_internal(
                 .block_size = sector_size,
                 .info = {
                         /* Use the specified flags, but configure the read-only flag from the open flags, and force autoclear */
-                        .lo_flags = (loop_flags & ~LO_FLAGS_READ_ONLY) | ((open_flags & O_ACCMODE) == O_RDONLY ? LO_FLAGS_READ_ONLY : 0) | LO_FLAGS_AUTOCLEAR,
+                        .lo_flags = (loop_flags & ~LO_FLAGS_READ_ONLY) | ((open_flags & O_ACCMODE_STRICT) == O_RDONLY ? LO_FLAGS_READ_ONLY : 0) | LO_FLAGS_AUTOCLEAR,
                         .lo_offset = offset,
                         .lo_sizelimit = size == UINT64_MAX ? 0 : size,
                 },
diff --git a/src/test/test-fileio.c b/src/test/test-fileio.c
index dbd175ad70..67943b65ba 100644
--- a/src/test/test-fileio.c
+++ b/src/test/test-fileio.c
@@ -1104,7 +1104,7 @@ TEST(fdopen_independent) {
         zero(buf);
         assert_se(fread(buf, 1, sizeof(buf), f) == strlen(TEST_TEXT));
         ASSERT_STREQ(buf, TEST_TEXT);
-        assert_se((fcntl(fileno(f), F_GETFL) & O_ACCMODE) == O_RDONLY);
+        assert_se((fcntl(fileno(f), F_GETFL) & O_ACCMODE_STRICT) == O_RDONLY);
         assert_se(FLAGS_SET(fcntl(fileno(f), F_GETFD), FD_CLOEXEC));
         f = safe_fclose(f);
 
@@ -1112,7 +1112,7 @@ TEST(fdopen_independent) {
         zero(buf);
         assert_se(fread(buf, 1, sizeof(buf), f) == strlen(TEST_TEXT));
         ASSERT_STREQ(buf, TEST_TEXT);
-        assert_se((fcntl(fileno(f), F_GETFL) & O_ACCMODE) == O_RDONLY);
+        assert_se((fcntl(fileno(f), F_GETFL) & O_ACCMODE_STRICT) == O_RDONLY);
         assert_se(!FLAGS_SET(fcntl(fileno(f), F_GETFD), FD_CLOEXEC));
         f = safe_fclose(f);
 
@@ -1120,7 +1120,7 @@ TEST(fdopen_independent) {
         zero(buf);
         assert_se(fread(buf, 1, sizeof(buf), f) == strlen(TEST_TEXT));
         ASSERT_STREQ(buf, TEST_TEXT);
-        assert_se((fcntl(fileno(f), F_GETFL) & O_ACCMODE) == O_RDWR);
+        assert_se((fcntl(fileno(f), F_GETFL) & O_ACCMODE_STRICT) == O_RDWR);
         assert_se(FLAGS_SET(fcntl(fileno(f), F_GETFD), FD_CLOEXEC));
         f = safe_fclose(f);
 }