diff --git a/src/run/run.c b/src/run/run.c
index 5d95ee8a22..6754b80bcf 100644
--- a/src/run/run.c
+++ b/src/run/run.c
@@ -723,6 +723,10 @@ static int parse_argv(int argc, char *argv[]) {
                 return log_error_errno(SYNTHETIC_ERRNO(EINVAL),
                                        "--pty-late is not compatible with --service-type=oneshot.");
 
+        if (sd_json_format_enabled(arg_json_format_flags) && arg_stdio != ARG_STDIO_NONE)
+                return log_error_errno(SYNTHETIC_ERRNO(EINVAL),
+                                       "--json= is not compatible with --pty/--pty-late/--pipe.");
+
         if (arg_scope && with_trigger)
                 return log_error_errno(SYNTHETIC_ERRNO(EINVAL),
                                        "Path, socket or timer options are not supported in --scope mode.");
diff --git a/test/units/TEST-74-AUX-UTILS.run.sh b/test/units/TEST-74-AUX-UTILS.run.sh
index acd7bc5b6c..a5c79ddb72 100755
--- a/test/units/TEST-74-AUX-UTILS.run.sh
+++ b/test/units/TEST-74-AUX-UTILS.run.sh
@@ -256,6 +256,7 @@ systemd-run --wait --pty true
 systemd-run --wait --machine=.host --pty true
 systemd-run --json=short true | jq . >/dev/null
 systemd-run --json=pretty true | jq . >/dev/null
+(! systemd-run --wait --pipe --json=short true)
 (! SHELL=/bin/false systemd-run --quiet --shell)
 
 (! systemd-run)